Last data update: May 13, 2024. (Total: 46773 publications since 2009)
Records 1-5 (of 5 Records) |
Query Trace: Soyseth V[original query] |
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Annual decline in forced expiratory volume is steeper in aluminum potroom workers than in workers without exposure to potroom fumes
Soyseth V , Henneberger PK , Einvik G , Virji MA , Bakke B , Kongerud J . Am J Ind Med 2016 59 (4) 322-9 BACKGROUND: Aluminum potroom exposure is associated with increased mortality of COPD but the association between potroom exposure and annual decline in lung function is unknown. We have measured lung volumes annually using spirometry from 1986 to 1996. The objective was to compare annual decline in forced expiratory volume in 1 s (dFEV1) and forced vital capacity (dFVC). METHODS: The number of aluminum potroom workers was 4,546 (81% males) and the number of workers in the reference group was 651 (76% males). The number of spirometries in the index group and the references were 24,060 and 2,243, respectively. RESULTS: After adjustment for confounders, the difference in dFEV1 and dFVC between the index and reference groups were 13.5 (P < 0.001) and -8.0 (P = 0.060) ml/year. CONCLUSION: Aluminum potroom operators have increased annual decline in FEV1 relative to a comparable group with non-exposure to potroom fumes and gases. |
Construction of a job exposure matrix to dust, fluoride, and polycyclic aromatic hydrocarbons in the Norwegian aluminum industry using prediction models
Soyseth V , Henneberger P , Virji MA , Bakke B , Kongerud J . Ann Occup Hyg 2015 59 (9) 1106-21 BACKGROUND: The Norwegian aluminum industry developed and implemented a protocol for prospective monitoring of employees' exposure using personal samplers. We analyzed these data to develop prediction lines to construct a job exposure matrix (JEM) for the period 1986-1995. METHODS: The protocol for personal monitoring of exposure was implemented in all seven Norwegian aluminum plants in 1986 and continued until 1995. Personal samplers were used to collect total dust, fluorides, and total polycyclic aromatic hydrocarbons (PAH). In addition, exposure could be categorized according to process, i.e. prebake, Soderberg, and 'other'. We constructed four-dimensional JEMs characterized by: Plant, Job descriptor, Process, and Year. Totally 8074, 6734, and 3524 measurements were available for dust, fluorides, and PAH, respectively. The data were analyzed using linear mixed models with two-way interactions. The models were assessed using the Akaike criterion (AIC) and unadjusted R 2. The significance level was set to 10% (two-sided) for retaining variables in the model. RESULTS: In 1986, the geometric mean (95% confidence interval in parentheses) for total dust, total fluorides, and PAH were 3.18 (0.46-22.2) mg m-3, 0.58 (0.085-4.00) mg m-3, and 33.9 (2.3-504) microg m-3, respectively. During 10 years of follow-up, the exposure to total dust, fluorides, and PAH decreased by 9.2, 11.7, and 14.9% per year, respectively. Each model encompassed from 49 to 72 significant components of the interaction terms. The interaction components were at least as important as the main effects, and 65 to 91% of the significant components of the interaction terms were time-dependent. CONCLUSION: Our prediction models indicated that exposures were highly time-dependent. We expect that the time-dependent changes in exposure are of major importance for longitudinal studies of health effects in the aluminum industry. |
Increased decline in pulmonary function among employees in Norwegian smelters reporting work-related asthma-like symptoms
Soyseth V , Johnsen HL , Henneberger PK , Kongerud J . J Occup Environ Med 2015 57 (9) 1004-8 OBJECTIVE: To investigate associations between work-related asthma-like symptoms (WASTH) and annual pulmonary function decline among employees of 18 Norwegian smelters. METHODS: A 5-year longitudinal study in which WASTH was defined as a combination of dyspnea and wheezing that improved on rest days and vacation. RESULTS: A total of 12,966 spirometry examinations were performed in 3084 employees. Crude annual decline in forced expiratory volume in 1 second (FEV1) (dFEV1) was 32.9 mL/yr (95% confidence interval, 30.5 to 35.3), and crude annual decline in forced vital capacity (FVC) (dFVC) was 40.9 mL/yr (37.8 to 43.9). After adjustment for relevant covariates, employees reporting WASTH showed higher dFEV1 by 16.0 m:/yr (3.4 to 28.6) and higher dFVC by 20.5 mL/yr (6.0 to 35.0) compared with employees not reporting WASTH. CONCLUSION: Work-related asthma-like symptom was associated with greater annual declines in FEV1 and FVC, indicating a restrictive pattern. |
The incidence of work-related asthma-like symptoms and dust exposure in Norwegian smelters
Soyseth V , Johnsen HL , Henneberger PK , Kongerud J . Am J Respir Crit Care Med 2012 185 (12) 1280-5 RATIONALE: The prevalence of respiratory symptoms among employees in smelters is positively associated with dust exposure. OBJECTIVES: To investigate the association between the incidence of work-related asthma-like symptoms (WASTH) and dust exposure. METHODS: All the employees were invited to participate in a 5-year longitudinal study. The outcome of WASTH was defined as the combination of dyspnea and wheezing improving on rest days or vacation in an individual who had no asthma previously. Information about smoking and occupational status was obtained from a questionnaire. A job exposure matrix of total dust was developed. Multivariate data analyses were performed using Cox regression. MEASUREMENTS AND MAIN RESULTS: The total follow-up time of the employees (n = 2,476) was 8,469 years, and the median follow-up time for participants was 4.0 years. During the follow-up, 91 employees developed WASTH, and the corresponding incidence rate for WASTH per 1,000 person-years was 8.9 (7.3-10.9) (95% confidence interval in parentheses). The risk ratio of WASTH increased significantly (P = 0.0001) with dust exposure in the middle and high categories (1.0-2.9 and ≥3.0 mg/m(3)). Stratified analyses showed that the effect of current dust exposure varied with both previous exposure (PE) to dust and fumes (P = 0.006) and airflow limitation (AFL) (P = 0.033). The final analyses showed that the risk ratios for WASTH per 1 mg/m(3) increase in current dust exposure were 1.1 (0.93-1.2), 1.4 (1.1-1.8), 1.6 (1.1-2.3), and 1.9 (1.2-3.0) for the categories (PE+/AFL-), (PE-/AFL-), (PE+/AFL+, and (PE-/AFL+). CONCLUSIONS: In conclusion, dust exposure was associated with an increased incidence of WASTH. |
Fixed FEV1/FVC ratio <0.7 for identifying airflow limitation: not a good idea in occupational settings
Hnizdo E , Petsonk EL . Occup Environ Med 2012 69 (3) 227 Dr Søyseth and colleagues recently reported an increased prevalence of airflow limitation in workers employed in the Norwegian smelting industry and significant associations with workplace dust exposures.1 The prevalence of airflow limitation was assessed using prebronchodilator spirometry and two measures of airflow limitation: FEV1/FVC ratio <0.7 and FEV1/FVC ratio <lower limit of normal (LLN). When compared across age categories (<35, 35–44, ≥45 years), the prevalence of airflow limitation based on the ratio <0.7 versus LLN was approximately doubled in the ≥45 years age categories across all levels of exposure duration (overall ≈17.6 vs ≈8.8%). The rate of FEV1 decline was increased for prevalent and incident cases of airflow limitation defined by both criteria, but it would be of interest to see the rates of decline for workers with FEV1/FVC <0.7 compared with those where the ratio is <LLN and ≥LLN. | The authors recommended that ‘in occupational healthcare settings, FEV1/FVC ratio <0.7 should be the preferred index for airflow limitation’. | Although we find the associations between airflow obstruction and occupational exposure to be convincing, we believe that the authors' recommendation regarding the preferred index of airflow limitation is not substantiated by their results (as well as others). The proportionate increase in the presence of obstruction comparing exposed and unexposed smelter workers was consistently greater using the FEV1/FVC ratio <LLN compared with the ratio <0.7 (table 21). Workers showed a highly significant effect of a 1 mg/m3 geometric mean dust exposure when using the ratio <LLN (p=0.01), but not the ratio <0.7 (p>0.05). Similarly, the effect of a 1 mg/m3 exposure to dusts of SiMn, FeMn and FeCr was highly significant using the ratio <LLN (p=0.005) but not the ratio <0.7 (p>0.05, table 41). |
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